Sun exposure behaviours as a compromise to paradoxical injunctions: Insight from a worldwide survey.

BACKGROUND: Behavioural interventions can improve attitudes towards sun protection but the impact remains inconsistent worldwide. OBJECTIVE: To assess awareness of and attitudes towards the multiple facets of sun exposure and suggest ways to improve prevention from overexposure to the sun in all geographical zones and multiple skin types. METHODS: Online survey was conducted from 28 September to 18 October 2021. Study population was selected from the Ipsos online Panel (3,540,000 panellists), aged ≥18 years, from 17 countries around the five continents. Demographics, sun-exposure habits and practices, understanding of risks and information on phototypes were documented and analysed using descriptive statistics. RESULTS: Eighty-eight per cent of participants knew that sunlight can cause skin health problems (90% phototypes I-II, 82% phototypes V-VI, >90% in American and European countries, 72% in Asia and 85% in Africa). Eighty-five per cent used some form of protection against sunlight, predominantly: Seeking shade (77%), avoiding the midday sun (66%), facial application of sunscreen (60%) and wearing protective clothing (44%). The perception of sunlight itself is positive ('it gives energy' for 82%; 'tanned skin looks attractive' for 72%), although less in Asian countries and among individuals with dark skin phototypes. Eighty-three per cent reported having experienced sunburn, mainly in Australia, Canada, USA, Germany, France and Russia, and among individuals with dark skin phototypes. Only 12% systematically/often used all types of protection during exposure to the sun and 23% believed it is safe to go out in the sun with no protection when their skin is already tanned. From 13% (skin phototype I) to 26% (phototype VI) reported not using any form of protection against the sun. Knowledge and habits were significantly superior among people who are accustomed to seeing a dermatologist for a complete skin exam. CONCLUSIONS: Dermatologists could play a crucial role in relaying novel prevention messages, more finely tailored to specific risks, populations and areas of the world.

The effects of UV filters on health and the environment.

Sunscreens are an important means of protection against sunburns, dyspigmentation, photoaging, and photocarcinogenesis. Sunscreens come in a variety of formulations that can protect against ultraviolet B (UVB) radiation, both UVB and ultraviolet A (UVA) radiation (broad-spectrum sunscreens), and UVB, UVA, and visible light (tinted broad-spectrum sunscreens). In the USA, there is currently a paucity of FDA-approved broad-spectrum filters on the market. Studies have identified the presence of multiple UV filters in water sources globally. Many laboratory studies have implicated the potential impact of UV filters on coral reef bleaching, the food chain, and human health. However, many of these studies are performed at concentrations that are much higher than those present in the natural environment. With increasing discussion surrounding the role of organic and inorganic UV filters as potential environmental pollutants over the past decade, approval of additional broad-spectrum filters would be an important means of alleviating the use of more controversial filters. The aim of this article is to review the effects of UV filters on health and the environment and explore potential adjunctive agents for photoprotection.

Photoprotection in skin of color.

As populations in many parts of the world are projected to become more racially diverse over the coming decades, we must better understand the unique characteristics of the skin of populations with skin of color (SOC). This review aims to highlight important physiologic and clinical considerations of photoprotection in SOC. Ultraviolet radiation and visible light affect dark and light skin differently. SOC populations have historically not been informed on photoprotection to the same degree as their light skinned counterparts. This has exacerbated dermatologic conditions in which SOC populations are disproportionately affected, such as hyperpigmentary disorders. Patients should be encouraged to utilize multiple methods of photoprotection, ranging from avoidance of sunlight during peak intensity hours, seeking shade, wearing sun-protective clothing and wide-brimmed hat, and applying sunscreen. Ideal sunscreens for SOC populations include those with UVA-PF/SPF ratios ≥ 2/3 and tinted sunscreens to protect against VL. Although there have been increased efforts recently, more research into photoprotection for SOC and targeted public education are required to disseminate photoprotection resources that are patient-centered and evidence-based.

Extrato de Polypodium leucotomos em fotoproteção tópica e oral: dez anos de experiência brasileira / Polypodium leucotomos extract in topical and oral photoprotection: ten years of Brazilian experience

O extrato de Polypodium leucotomos foi inicialmente descrito na literatura internacional há 55 anos, demonstrando ação anti-inflamatória em dermatoses como vitiligo e psoríase. Atualmente, está disponível como fotoprotetor oral e tópico em mais de 26 países e é utilizado na prevenção e no tratamento de dermatoses decorrentes da radiação solar, como erupção polimorfa à luz, melasma, queratoses actínicas, câncer de pele, fotoenvelhecimento, entre outras. No Brasil, o extrato patenteado das folhas de Polypodium leucotomos foi registrado pela Agência Nacional de Vigilância Sanitária (Anvisa) como medicamento em 2012. Decorridos 10 anos de sua introdução no Brasil, sua recomendação por dermatologistas brasileiros está consagrada e será apresentada neste artigo

Polypodium leucotomos extract was first described in the literature 55 years ago, demonstrating anti-inflammatory action in dermatoses such as vitiligo and psoriasis. It is currently available as an oral and topical photoprotection agent in more than 26 countries to prevent and treat dermatoses resulting from solar radiation, such as polymorphous light eruption, melasma, actinic keratoses, skin cancer, and photoaging, among others. In Brazil, ANVISA registered the patented Polypodium leucotomos extract in 2012. After 10 years of its launch, its recommendation by Braziliandermatologists is well established and is presented in this review paper

Innovative digital solution supporting sun protection and vitamin D synthesis by using satellite-based monitoring of solar radiation.

Public health campaigns advise minimising UV radiation (UVR) exposure to prevent skin cancer and precancer, e.g. actinic keratosis (AK). A 3-day clinical field study, in Brazil, was performed to evaluate the mobile app Sun4Health® by siHealth Ltd. The app performs real-time monitoring of both erythemal and vitamin D-effective solar radiation doses using satellite data, enabling personalised recommendations on optimal sun exposure time and sunscreen use. When coupled to a wearable device, the app also provides body-site specific recommendations ("3D" version). 59 healthy volunteers were randomised into 3 groups, each given a different app providing: (1) ultraviolet index only (control app), (2) personalised recommendations and sun overexposure alerts (Sun4Health® app), (3) as (2) but connected via Bluetooth to a wearable device to monitor sun exposure in 3D (Sun4Health®-3D app). Participants were offered sunscreens (SPF 30 and 50) to use at their discretion. Erythema, quantified by reflectance spectroscopy, was assessed daily in the mornings and evenings on six body sites. Serum vitamin D (25(OH)D3) was measured before and after the study. Mean increase of erythema (Mexameter® units ± SD) of all exposed body sites combined over 3 days showed 55.76 ± 47.47 for group 1, 40.27 ± 37.91 for group 2 and 37.12 ± 30.69 for group 3 (p < 0.05 for all groups). Mean increase of serum 25(OH)D3 (nmol/l ± SD) showed 1.32 ± 36.49 for group 1, 6.38 ± 21.19 for group 2 and 18.68 ± 35.45 for group 3 (p > 0.05 for all groups). The results show that the Sun4Health® app is safe to use and can modify behaviour to reduce skin erythema (sunburn) yet not decreasing vitamin D status.

Expert Recommendations on the Evaluation of Sunscreen Efficacy and the Beneficial Role of Non-filtering Ingredients.

A variety of non-filtering agents have been introduced to enhance sunscreen photoprotection. Most of those agents have only weak erythema protective properties but may be valuable and beneficial in supporting protection against other effects of UV radiation, such as photoimmunosuppression, skin aging, and carcinogenesis, as well as photodermatoses. The question arises how to measure and evaluate this efficacy since standard SPF testing is not appropriate. In this perspective, we aim to provide a position statement regarding the actual value of SPF and UVA-PF to measure photoprotection. We argue whether new or additional parameters and scales can be used to better indicate the protection conferred by these products against the detrimental effects of natural/artificial, UV/visible light beyond sunburn, including DNA damage, photoimmunosuppression and pigmentation, and the potential benefits of the addition of other ingredients beyond traditional inorganic and organic filters to existing sunscreens. Also, we debate the overall usefulness of adding novel parameters that measure photoprotection to reach two tiers of users, that is, the general public and the medical community; and how this can be communicated to convey the presence of additional beneficial effects deriving from non-filtering agents, e.g., biological extracts. Finally, we provide a perspective on new challenges stemming from environmental factors, focusing on the role of the skin microbiome and the role of air pollutants and resulting needs for photoprotection.

Daily photoprotection to prevent photoaging.

BACKGROUND: Extrinsic skin aging or photoaging was previously thought to be almost exclusively due to solar ultraviolet (UV) radiation. However, recent literature has described other contributing factors and clarification is thus required as to what extent and what type of daily photoprotection is needed to mitigate extrinsic skin aging. METHODS: We reviewed the existing scientific evidence on daily photoprotection, and specific requirements at the product level, to prevent extrinsic skin aging. We critically reviewed the existing evidence on potential ecological and toxicological risks which might be associated with daily photoprotection. RESULTS: Evidence shows that broad protection against the entire solar range of UVB, UVA, UVA1, visible light, and short infrared (IRA) is required to prevent extrinsic aging. Other exposome factors, such as air pollution and smoking, also contribute to skin aging. Daily broad-spectrum sunscreen photoprotection should thus contain antioxidant ingredients for additional benefits against UV, IRA, and pollution-induced oxidative stress as well as anti-aging active ingredients to provide clinical benefits against skin aging signs, such as wrinkles and dark spots. Broad-spectrum sunscreen containing pigments, such as iron oxide, may be required for melasma prevention. There is no conclusive clinical evidence that daily sunscreen use is unsafe or that it compromises vitamin D synthesis. CONCLUSION: Daily use of broad-spectrum sunscreen containing antioxidant and anti-aging active ingredients can effectively reduce extrinsic aging.

A novel method for evaluating sun visible light protection factor and pigmentation protection factor of sunscreens.

INTRODUCTION: The role of visible light (VL) in the process of skin pigmentation by solar radiation has been demonstrated. Sunscreens with the presence of pigments, particularly iron oxide (IO), have a greater protective effect against VL and are, therefore, highly recommended for prevention and treatment of hyperpigmentation disorders. This study aimed to evaluate 33 sunscreen formulations, and through spectrophotometric measurements, proposes new methods to evaluate the VL protection factor and the pigmentation protection factor. METHODS: 33 sunscreen formulations marketed in Brazil were evaluated, including 17 products containing pigments and 16 products with no pigments. Spectrophotometric measurements were taken to determine solar VL protection factor and the pigmentation protection factor, based on the absorption curve of the product, the pigmentation action spectrum and sun spectrum. RESULTS: Sunscreen with pigments presented a higher solar VL protection factor and pigmentation protection factor compared to products without pigment. The statistical analysis showed a strong correlation between the solar VL protection factor and the integral of the absorption curve in the VL range and the transmittance reduction (%) in the same range. The correlation between the VL protection factor and the pigmentation protection factor was also demonstrated. CONCLUSION: The VL protection factor and the pigmentation protection factor showed to be adequate metrics to estimate the effectiveness of sunscreens in the prevention of the pigmentary effect of solar VL and the pigmentary effect of the complete spectrum of immediate pigmentation.

Composto nutracêutico no tratamento do eflúvio telógeno associado à síndrome das unhas fracas / Nutraceutical compound for the treatment of telogen effluvium associated with brittle nails syndrome

Introdução: O uso de produtos nutracêuticos no tratamento do eflúvio telógeno crônico de causa inespecífica, associado ou não a sinais e sintomas de fragilidade da lâmina ungueal, tem sido proposto na literatura. A suplementação de nutrientes e oligoelementos essenciais ao metabolismo do folículo parece ser o mecanismo relacionado a esse efeito. Objetivo: Avaliar a eficácia de nutracêutico contendo, entre outros elementos, vitaminas A, C, E, complexo B, ácido fólico, ferro, niacina, biotina, zinco e pantetonato de cálcio, no tratamento do eflúvio telógeno associado à síndrome das unhas fracas. Métodos: Estudo clínico, prospectivo, aberto e unicêntrico, com avaliação de 62 voluntárias. Medidas de avaliação clínica, por fototricograma digital e por imagem, foram realizadas na visita inicial, 45 e 90 dias após o uso do produto estudado. Resultados: Ao final do estudo, observou-se redução estatisticamente significativa (p < 0,05) de 31,56% do número de fios telógenos, acompanhado de melhora significativa nos parâmetros clínicos relacionados aos cabelos e às unhas. A avaliação instrumental por análise de imagens demonstrou redução de 36,63% da descamação das unhas, que, embora não estatisticamente significativa, demonstrou benefícios no resultado absoluto. Conclusões: O uso de produto nutracêutico demonstrou eficácia no tratamento do eflúvio telógeno associado à síndrome das unhas frágeis.

Introduction: The use of nutraceutical products in the treatment of chronic telogen effluvium of non- -specific cause ­ associated or not with signs and symptoms of nail plate frailty ­ has been proposed in the literature. Supplementation of nutrients and trace elements that are crucial to follicle's metabolism seems to be linked to this effect. Objective: To evaluate the efficacy of a nutraceutical containing vitamins A, C, E and B complex, folic acid, iron, niacin, biotin, zinc and calcium pantetonate, among others, in the treatment of telogen effluvium associated with the brittle nails syndrome. Methods: A clinical, prospective, open and monocentric study was carried out with the evaluation of 62 volunteers. Clinical evaluation measurements ­ based on digital phototrichogram and imaging ­ were performed at the baseline, and at 45 and 90 days after the use of the studied product. Results: At the end of the study, a statistically significant (p <0.05) reduction of 31.56% in the number of telogen strands could be observed, coupled with a significant improvement in clinical parameters related to hair and nails. The instrumental evaluation based on image analysis showed a 36.63% reduction in nail desquamation, which, although not statistically significant, has shown benefits in the absolute outcome. Conclusions: The use of nutraceuticals was proven effective in the treatment of telogen effluvium associated with the brittle nails syndrome.

Composto nutracêutico aumenta a síntese de colágeno, elastina e ácido hialurônico / Nutraceutical compound increases collagen, elastin and hyaluronic acid synthesis

Introdução: O uso de produtos nutracêuticos com a finalidade de atenuar os sinais do envelhecimento da pele tem sido proposto na literatura. O estímulo à síntese de elementos de sustentação da derme é um dos mecanismos relacionados a esse efeito. Objetivo: Avaliar a eficácia de um nutracêutico contendo luteína, licopeno, vitamina C e mangânes na síntese de colágeno, elastina e ácido hialurônico. Métodos: Estudo realizado in vitro, através de cultura de fibroblastos humanos tratadas com o produto investigado em diferentes concentrações não citotóxicas. A quantificação de elastina e colágeno foi determinada através de medidas espectrofotométricas enquanto que a de ácido hialurônico foi determinada por método imunoenzimático. Resultados: As culturas celulares tratadas com as diferentes concentrações do produto apresentaram quantidade sintetizada de colágeno, elastina e ácido hialurônico significativamente maior quando comparadas com a cultura não tratada (p<0,05). Conclusões: O uso de nutracêutico contendo licopeno, vitamina C, luteína e manganês demonstrou eficácia in vitro no estímulo à síntese de colágeno, elastina e ácido hialurônico, elementos essenciais na estrutura de sustentação da derme e responsáveis pelas características de firmeza e elasticidade da pele.

Introduction: The use of nutraceutical products in order to attenuate signs of skin aging has been proposed in the literature. The stimulus to the synthesis of substances that support the dermis is one of the mechanisms linked to this effect. Objective: To evaluate the effectiveness of a nutraceutical compound containing lutein, lycopene, vitamin C and manganese for the synthesis of collagen, elastin and hyaluronic acid. Methods: An in vitro study was carried out based on the culture of human fibroblasts treated with the investigated product in different non-cytotoxic concentrations. The quantification of the elastin and collagen was performed with the assistance of spectrophotometric measurements. Hyaluronic acid was measure using a immunoenzymatic method. Results: Cell cultures treated with the different concentrations of the product showed a significantly higher amount of synthesized collagen, elastin and hyaluronic acid as compared to the untreated culture (p <0.05). Conclusions: The use of the nutraceutical compound containing lycopene, vitamin C, lutein and manganese has shown in vitro efficacy for stimulating the synthesis of collagen, elastin and hyaluronic acid, components that are crucial for providing the dermis' supporting structure, being responsible for the skin's firmness and elasticity.

Physiological and lifestyle factors contributing to risk and severity of peri-orbital dark circles in the Brazilian population.

BACKGROUND: Peri-orbital dark circles are a cosmetic concern worldwide, and have been attributed to hyperpigmentation from allergy or atopic dermatitis, blood stasis, structural shadowing effects, and a thin epidermis/dermis under the eye. It is of interest to better understand lifestyle and demographic risk factors and the relative impact of melanin, blood and epidermal/dermal factors on the severity of Peri-orbital dark circles. OBJECTIVE: To compare by non-invasive imaging the impact of biological factors to a visual grading scale for Peri-orbital dark circles, and test the correlation of various demographic factors with Peri-orbital dark circles. METHODS: Subjects completed a lifestyle and health survey, and Peri-orbital dark circles severity was evaluated using standardized photographs. Hyperspectral image analysis was used to assess the contributions of melanin, blood volume, degree of blood oxygen saturation, and dermal scattering. RESULTS: Family history was the most significant risk factor for Peri-orbital dark circles. The average age of onset was 24 years, and earlier onset correlated with higher severity scores. Asthma was significantly associated with Peri-orbital dark circles scores, but self-reported allergy was not. In this study, sleep was not correlated with Peri-orbital dark circles scores. Hyperspectral imaging indicated that melanin was the dominant correlate for Peri-orbital dark circles severity, while oxygen saturation was secondary. The difference between under-eye and cheek measurements for ΔL*and ΔE* were the most significant instrumental parameters correlated with visual assessment of Peri-orbital dark circles severity. CONCLUSION: Although typically associated with lack of sleep, risk of Peri-orbital dark circles is primarily hereditary. The main factors contributing to the appearance of Peri-orbital dark circles are melanin and (deoxygenated) blood.

Physiological and lifestyle factors contributing to risk and severity of peri-orbital dark circles in the Brazilian population

AbstractBACKGROUND:Peri-orbital dark circles are a cosmetic concern worldwide, and have been attributed to hyperpigmentation from allergy or atopic dermatitis, blood stasis, structural shadowing effects, and a thin epidermis/dermis under the eye. It is of interest to better understand lifestyle and demographic risk factors and the relative impact of melanin, blood and epidermal/dermal factors on the severity of Peri-orbital dark circles.OBJECTIVE:To compare by non-invasive imaging the impact of biological factors to a visual grading scale for Peri-orbital dark circles, and test the correlation of various demographic factors with Peri-orbital dark circles.METHODS:Subjects completed a lifestyle and health survey, and Peri-orbital dark circles severity was evaluated using standardized photographs. Hyperspectral image analysis was used to assess the contributions of melanin, blood volume, degree of blood oxygen saturation, and dermal scattering.RESULTS:Family history was the most significant risk factor for Peri-orbital dark circles. The average age of onset was 24 years, and earlier onset correlated with higher severity scores. Asthma was significantly associated with Peri-orbital dark circles scores, but self-reported allergy was not. In this study, sleep was not correlated with Peri-orbital dark circles scores. Hyperspectral imaging indicated that melanin was the dominant correlate for Peri-orbital dark circles severity, while oxygen saturation was secondary. The difference between under-eye and cheek measurements for ΔL*and ΔE* were the most significant instrumental parameters correlated with visual assessment of Peri-orbital dark circles severity.CONCLUSION:Although typically associated with lack of sleep, risk of Peri-orbital dark circles is primarily hereditary. The main factors contributing to the appearance of Peri-orbital dark circles are melanin and (deoxygenated) blood.

Brazilian Consensus on Photoprotection

Brazil is a country of continental dimensions with a large heterogeneity of climates and massive mixing of the population. Almost the entire national territory is located between the Equator and the Tropic of Capricorn, and the Earth axial tilt to the south certainly makes Brazil one of the countries of the world with greater extent of land in proximity to the sun. The Brazilian coastline, where most of its population lives, is more than 8,500 km long. Due to geographic characteristics and cultural trends, Brazilians are among the peoples with the highest annual exposure to the sun. Epidemiological data show a continuing increase in the incidence of non-melanoma and melanoma skin cancers. Photoprotection can be understood as a set of measures aimed at reducing sun exposure and at preventing the development of acute and chronic actinic damage. Due to the peculiarities of Brazilian territory and culture, it would not be advisable to replicate the concepts of photoprotection from other developed countries, places with completely different climates and populations. Thus the Brazilian Society of Dermatology has developed the Brazilian Consensus on Photoprotection, the first official document on photoprotection developed in Brazil for Brazilians, with recommendations on matters involving photoprotection.

Estudo clínico aberto para avaliação de segurança e tolerabilidade de lubrificante para uso íntimo / Open clinical trial to evaluate the safety and tolerability of a personal lubricant

Introdução: O uso de lubrificantes íntimos pode ser recomendado para reduzir o desconforto da lubrificação insuficiente, proporcionando conforto aos parceiros, particularmente em mulheres portadoras de ressecamento vaginal, decorrente da menopausa ou por outras condições ginecológicas1. Os lubrificantes íntimos são compostos por géis inertes ou que contenham ingredientes com ação calmante1. O presente estudo avaliou a segurança e a tolerabilidade de um gel lubrificante íntimo. Métodos: 115 voluntárias foram avaliados nas etapas do estudo. Inicialmente 55 voluntárias participaram de uma etapa para avaliação de potencial irritante primário e cumulativo e sensibilizante, através de aplicações repetidas de apósitos oclusivos no dorso. Paralelamente 27 voluntárias participaram de uma etapa para avaliação de potencial fotoirritante e fotossensibilizante através de aplicações repetidas de apósitos oclusivos, combinadas com irradiação com UVA. Finalmente, 35 voluntárias com queixas de dispareunia e ressecamento vaginal participaram de um estudo sob condições normais de uso, com utilização do produto durante 21 dias. As voluntárias responderam a um questionário sobre a performance do produto. Resultados: Não foi observada nenhuma positividade nos estudos de dermatotoxicologia. No estudo de segurança e tolerabilidade, nenhum evento adverso foi observado. O produto foi bem avaliado pela maior parte dos voluntários, que referiram maior lubrificação e sensação de bem-estar durante o ato sexual. Conclusão: O lubrificante íntimo avaliado no presente estudo demonstrou ser seguro e foi capaz de promover uma melhora da lubrificação íntima, promovendo uma melhor qualidade do ato sexual. O produto pode ser declarado como hipoalergênico, pela ausência de positividade nos estudos de dermatotoxicologia...

Efeito do uso de gel não hormonal na região genital em mulheres na pós-menopausa / Effect of the use of no hormonal gel in genital region in postmenopausal women

Introdução: A queixa genital é comum em mulheres menopausadas. A diminuição dos níveis de estrogênio neste período causa atrofia vulvovaginal que pode ser acompanhada de vaginite, prurido, dispareunia, dentre outros sintomas. Objetivo: O objetivo deste estudo foi avaliar o efeito da utilização de um gel não hormonal a base de extratos vegetais em mulheres menopausadas com queixas vulvovaginais. Método: Trinta e cinco voluntárias, com idade entre 45 e 65 anos, com vida sexual ativa e em menopausa há pelo menos 6 meses, realizaram aplicações diárias vulvares do gel por quatro semanas. Todas as pacientes responderam a um questionário não estruturado com questões referentes ao conforto durante a relação sexual, hidratação e maciez genital no final do tratamento. Resultados: Todas as pacientes referiram mais conforto na atividade sexual. Houve melhora da hidratação da região genital em 97% e sensação de maciez local em 100% das pacientes. Conclusão: A utilização do gel não hormonal promoveu maior hidratação e maciez tecidual genital melhorando a sexualidade.

Brazilian consensus on photoprotection.

Brazil is a country of continental dimensions with a large heterogeneity of climates and massive mixing of the population. Almost the entire national territory is located between the Equator and the Tropic of Capricorn, and the Earth axial tilt to the south certainly makes Brazil one of the countries of the world with greater extent of land in proximity to the sun. The Brazilian coastline, where most of its population lives, is more than 8,500 km long. Due to geographic characteristics and cultural trends, Brazilians are among the peoples with the highest annual exposure to the sun. Epidemiological data show a continuing increase in the incidence of non-melanoma and melanoma skin cancers. Photoprotection can be understood as a set of measures aimed at reducing sun exposure and at preventing the development of acute and chronic actinic damage. Due to the peculiarities of Brazilian territory and culture, it would not be advisable to replicate the concepts of photoprotection from other developed countries, places with completely different climates and populations. Thus the Brazilian Society of Dermatology has developed the Brazilian Consensus on Photoprotection, the first official document on photoprotection developed in Brazil for Brazilians, with recommendations on matters involving photoprotection.

Avaliação comparativa de segurança e eficácia para produtos de higiene íntima em mulheres na menopausa / Comparative evaluation of safety and efficacy for hygiene products in menopausal women

Justificativa e objetivo: A menopausa é a última menstruação, um marco no período do climatério, momento de grandes modificações na vida da mulher. O objetivo deste estudo foi avaliar a segurança e eficácia hidratante e restauradora da mucosa, de um produto de higiene íntima em pacientes menopausadas. Métodos: Estudo envolvendo 70 voluntárias, sexo feminino, com idade entre 45 e 65 anos, randomizadas em dois grupos com 35 integrantes. Cada grupo utilizou uma fragrância do produto investigacional por 15 dias e, posteriormente, foi acrescentado ao produto investigacional uma loção hidratante por mais 15 dias. Após um intervalo de 7 dias as voluntárias utilizaram o produto-controle por mais 30 dias. A avaliação da eficácia foi realizada através da corneometria (avaliação da hidratação) e da evaporimetria (medida de perda de água transepidérmica - TEWL). Foram realizadas avaliações subjetivas, com a aplicação de questionários realizados no início e fim do tratamento para cada produto. Resultados: O produto-controle demonstrou resultado significativamente superior quanto à melhora da sensação de elasticidade da mucosa genital e da sensação de firmeza da mucosa genital, em comparação ao produto investigacional fragrância Silver Frutal. A associação de loção hidratante ao produto investigacional fragrâncias Silver Frutal e Silver Floral demonstrou resultados positivos nos parâmetros avaliados, exceto para viscosidade. Quanto à segurança, nenhuma das voluntárias apresentou reação alérgica ou outra reação adversa. Conclusão: Os produtos de higiene íntima feminina devem auxiliar a manutenção das condições genitais fisiológicas e possuir uma alta margem de segurança que possibilite o uso em mulheres menopausadas saudáveis.

Avaliação comparativa de segurança e eficácia na redução de odores e melhora da hidratação genital para produtos de higiene íntima / Comparative evaluation of safety and efficacy in reducing odors and improves genital hydration for hygiene products

Justificativa e objetivo: É importante que a mulher se sinta segura e protegida contra odores genitais desagradáveis. O objetivo deste estudo foi avaliar a segurança e eficácia na melhora da hidratação genital e redução de odores de um produto de higiene íntima. Métodos: Estudo envolvendo 230 voluntárias, com idade entre 18 e 45 anos, randomizadas em cinco grupos com 46 integrantes. Utilizou-se o produto investigacional por 30 dias e o produto-controle por mais 30 dias, com intervalo de 7 dias entre os tratamentos. Cada grupo utilizou uma fragrância diferente do produto investigacional, totalizando cinco fragrâncias. A avaliação da eficácia foi subjetiva, através de questionário aplicado no início e no fim do tratamento para cada produto (investigacional e controle). Foram avaliadas como variáveis, a redução do odor genital, o aumento da hidratação genital e a percepção sensorial quanto aos itens espumação, facilidade de remoção do produto na região vaginal, toque final na mucosa, fragrância final e sensação de limpeza. Ao final do protocolo, outro questionário foi aplicado comparando diretamente o produto investigacional e o produto-controle nos quesitos redução de odor vaginal e sensação de limpeza. Resultados: O produto investigacional demonstrou melhores avaliações em todos os parâmetros, para as cinco fragrâncias, 30 dias após a aplicação. Quanto à segurança do produto, nenhuma das voluntárias apresentou reação adversa. Conclusão: Os cuidados com a região genital feminina devem ser feitos de maneira adequada, promovendo sensação de proteção e bem-estar às mulheres, com produtos desenvolvidos especialmente para a região íntima e com eficácia comprovada.

Estudo clínico para avaliação do filtro solar Filtrum FPS 50 Alta Proteção: avaliação cosmética / Clinical study of sunscreen SPF 50 Filtrum Alta Proteção: cosmetics assessment

Este estudo clínico foi realizado com Filtrum FPS 50 Alta Proteção em voluntários saudáveis. Realizou-se avaliação sensorial...